Bio-peptidi disponibili

Peptidi disponibili in stock

bio-peptidi

Substrati Specifici in Protein Kinase (1mg, 3mg)

code substrate  |  protein kinase
PKA-001 LRRASLG  |  PKA (1)
PKC-002 QKRPSQRSKYL  |  PKC(2)
AKT-003  RPRAATF  |  Akt/PKB(3) 
CDC-004  Ac-SPGRRRRK  |  CDC2 (4) 
CK1-005  RRKDLHDDEEDEAMSITA  |  CK1 (5)
CK2-006  RRRADDSDDDDD  |  CK2(6)
CK2-007  MSGDEMIFDPTMSKKKKKKKKP  |  CK2(7)holoenzyme
DIR-008  KKISGRLSPIMTEQ  |  DYRK(8)
GSK-009  YRRAAVPPSPSLSRHSSPHQpSEDEEE  |  GSK3α,β(9)
AUR-0010  YALKRASLGAA  |  Aurora-A(10) 
PIM-0011  ARKRRRHPSGPPTA  |  PIM

Cell Penetrating Peptides (1mg, 3mg)

code sequence  |  name
PEN-001 RQIKIWFQNRRMKWKK-NH2  |  Penetratin (11)
TAT-001 GRKKRRQRRRPPQ-NH2  |  HIV-TAT[48-60] (12)
TAT-002 GYGRKKRRQRRRG-NH2  |  HIV-TAT[G-47-57-G] (12)
R9-001 RRRRRRRRR  |  ARG9 Peptide
BUF-001 TRSSRAGLQFPVGRVHRLLRK  |  Buforina
MAST-001 INLKALAALAKKIL-NH2  |  Mastoparan Peptide
TRAS-001 GWTLNSAGYLLGKINLKALAALAKKIL  |  Transportan Peptide

  References

  1. Maller JL, Kemp BE, Krebs EG (1978) “In vivo phosphorylation of a synthetic peptide substrate of cyclic AMP-dependent protein kinase.” Proc Natl Acad Sci U S A. 75(1):248-51.
  2. Yasuda I, Kishimoto A, Tanaka S, Tominaga M, Sakurai, Nishizuka Y (1990) A synthetic peptide substrate for selective assay of protein kinase C. Biochem Biophys Res Commun 166:1220-7.
  3. Alessi DR, Caudwell FB, Andjelkovic M, Hemmings BA, Cohen P (1996) Molecular basis for the substrate specificity of protein kinase B: comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett 399:333-8.
  4. Srinivasan J, Koszelak M, Mendelow M, Kwon YG, Lawrence DS (1995) The design of peptide-based substrates for cdc2 protein kinase. Biochem J 309 (Pt 3): 927-31.
  5. Marin O, Meggio F, Pinna LA (1994) Design and synthesis of two new peptide substrates for the specific and sensitive monitoring of casein kinase-1 and-2. Biochem Biophys Res Commun 198: 898-905.
  6. Meggio F, Marin O, Pinna LA. (1994) Substrate specificity of protein kinase CK2. Cell Mol Biol Res 40, 401-9
  7. Salvi M, Sarno S, Marin O, Meggio F, Itarte e, Pinna LA (2006) Discrimination between the activity of protein kinase CK2 holoenzyme and its catalytic subunits FEBS LETT 580 (16): 3948-3952 JUL 10 2006
  8. G Woods YL, Rena G, Cohen P et al. (2001) "The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation site" Biochem J. 355(Pt 3):597-607
  9. H Sutherland C, Leighton IA, Cohen P (1993) Inactivation of glycogen synthase kinase-3 beta by phosphorylation: kinase connection in insulin and growth factor signalling. Biochem J 296 (Pt 1):15-9.
  10. Ferrari S, Marin O, Pagano Ma, Meggio F, Hess D, El-Shemerly M, Krystyniak A, Pinna La Aurora-A site specificity: a study with synthetic peptide substrates Biochem J 390: 293-302Part 1 Aug 15 2005
  11. Y-H. Chiu, C Alvarez-Baron, E. Y. Kim and S. E. Dryer. 2010. Dominant-Negative Regulation of Cell Surface Expression by a Pentapeptide Motif at the Extreme COOH Terminus of an Slo1 Calcium-Activated Potassium Channel Splice Variant. Molecular Pharmacology 2010 vol. 77 no. 4 497-507
  12. S. Sandgren, F. Cheng, M. Belting. 2002. Nuclear Targeting of Macromolecular Polyanions by an HIV-Tat Derived Peptide. J. Biol. Chem. 2002 Vol. 277, No. 41, pp. 38877-38883