Protein Interactions and Dynamics

Description

My research aims at understanding complex cellular processes via comprehensive description of protein interactions and dynamics. We study the role of protein condensation in biochemical pathways and the pathological conversion of liquid droplets. We also develop sequence-based prediction methods to identify fuzzy interactions from sequence and protein regions capable of mediating liquid-liquid phase separation.

Recent publications

Boeynaems S, Alberti S, Fawzi NL, Mittag T, Polymenidou M, Rousseau F, Schymkowitz J, Shorter J, Wolozin B, Van Den Bosch L, Tompa P, Fuxreiter M. (2018) Protein phase separation: a new phase in cell biology. Trends Cell Biol. 28, 420-435.

Wu, H, Fuxreiter M (2016) The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules. Cell 165, 1055-1066.

Fuxreiter M (2018) Fuzziness in protein interactions - A historical perspective. J. Mol. Biol. 430, 2278-2287

M. Hardenberg, A. Horvath, V. Ambrus, M. Fuxreiter, M. Vendruscolo (2020) Wide-spread occurrence of the droplet state of proteins in the human proteome. PNAS. 117(52), 33254-33262. doi: 10.1073/pnas.2007670117

Gianni S, Freiberger MI, Jemth P, Ferreiro DU, Wolynes PG,Fuxreiter M. (2021) Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly. Acc Chem Res. doi: 10.1021/acs.accounts.0c00813