Redox signalling and cancer biomarkers


Our interests are above referred to oxidative stress, redox regulation in normal and tumoral cells. In particular, our studies are developed mitochondrial redox regulation especially in relation with glutathione and thioredoxin systems. Thioredoxin system- thioredoxin, thioredoxin reductase and peroxiredoxins-is analyzed also in relation to redox signalling. Inhibitors of thioredoxin reductase such as metal complexes are evaluated and consequently the redox state of the protein targets are investigated.

A second topic of interest is the role of antioxidant molecules in human nutrition.



J Med Chem Award 2012.pdf J Med Chem Award 2012

Highly Cited Paper Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs



Federica Tonolo:

Laura Moretto:


5 recent publications

  1. Tonolo F, Salmain M, Scalcon V, Top S, Pigeon P, Folda A, Caron B, McGlinchey MJ, Toillon RA, Bindoli A, Jaouen G, Vessières A, Rigobello MP. Small Structural Differences between Two Ferrocenyl Diphenols Determine Large Discrepancies of Reactivity and Biological Effects. ChemMedChem. 2019 Sep 4. doi: 10.1002/cmdc.201900430. PMID: 31483560
  2. Scalcon V, Tonolo F, Folda A, Bindoli A, Rigobello MP. Dimers of glutaredoxin 2 as mitochondrial redox sensors in selenite-induced oxidative stress. Metallomics. 2019 Jul 17;11(7):1241-1251. doi: 10.1039/c9mt00090a. PMID: 31168542
  3. Scalcon V, Bindoli A, Rigobello MP. Significance of the mitochondrial thioredoxin reductase in cancer cells: An update on role, targets and inhibitors. Free Radic Biol Med. 2018 Nov 1; 127:62-79. doi: 10.1016/j.freeradbiomed.2018.03.043. Epub 2018 Mar 27.
  4. Folda A, Citta A, Scalcon V, Calì T, Zonta F, Scutari G, Bindoli A, Rigobello MP. Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State. Sci Rep. 2016 Mar 15;6:23071. doi: 10.1038/srep23071.
  5. Citta A, Folda A, Scalcon V, Scutari G, Bindoli A, Bellamio M, Feller E, Rigobello MP. Oxidative changes in lipids, proteins, and antioxidants in yogurt during the shelf life. Food Sci Nutr. 2017 Jul 25;5(6):1079-1087. doi: 10.1002/fsn3.493. eCollection 2017 Nov.


Peptidi Bioattivi antiossidanti:

  1. Tonolo F, Moretto L, Folda A, Scalcon V, Bindoli A, Bellamio M, Feller E, Rigobello MP. Antioxidant Properties of Fermented Soy during Shelf Life. Plant Foods Hum Nutr. 2019 Sep;74(3):287-292. doi: 10.1007/s11130-019-00738-6. PMID: 31098881
  2. Tonolo F, Moretto L, Ferro S, Folda A, Scalcon V, Sandre M, Fiorese F, Marin O, Bindoli A, Rigobello MP. Insight into antioxidant properties of milk-derived bioactive peptides in vitro and in a cellular model. J Pept Sci. 2019 May;25(5):e3162. doi: 10.1002/psc.3162. Epub 2019 Mar 12.
  3. Tonolo F, Sandre M, Ferro S, Folda A, Scalcon V, Scutari G, Feller E, Marin O, Bindoli A, Rigobello MP. Milk-derived bioactive peptides protect against oxidative stress in a Caco-2 cell model. Food Funct. 2018 Feb 21;9(2):1245-1253. doi: 10.1039/c7fo01646h. PMID: 29387856