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Geppo Sartori, born on May 16, 1966, is Research Associate in Molecular Biology at the Department of Biomedical Sciences (DSB) of the University of Padova since february 2001. In the 1992 he obtained his degree in Biological Sciences at the University of Padova by discussing a thesis concerning his contribute to the sequencing of the yeast Saccharomyces cerevisiae genome. In the year 1994 he started a PhD course in Biochemistry and Biophisics, which was devoted to the functional analysis of a yeast gene, named YNL234w, coding for a protein belonging to the hemoglobins family but characterized by an unusual structure. His work has clarified some aspects of the YNL234w transcription regulation and of some biochemical characteristics of the corresponding protein. After the PhD degree he continued his work (partly in the J. Verdière laboratory at C.G.M. of C.N.R.S., Gif sur Yvette, France) to study in detail some aspects of gene transcription regulation by oxygen in yeast. At the same time, his research work has been devoted to a large scale functional analysis of unknown yeast genes and, in particular, to the in-depth study of Bud32, an unusual protein kinase that is part of KEOPS, a multiprotein complex involved in transcription regulation and telomere homeostasis. More recently he started a new research project, in collaboration with Dr. Leonardo Salviati (Department of Pediatrics, University of Padova), focused on the use of yeast as a model to characterize several mutations responsible for human mitochondrial encephalomyopathies.
2005 – 2012: “Tecnologia del DNA ricombinante” course in the first level degree in “Biotecnologie Sanitarie”
Since 2013: “Biologia Molecolare” course, degree in “Farmacia”
The yeast S. cerevisiae has been historically considered as a model organism for the study of some basal processes in the eukaryotic cells, since a number of factors are conserved throughout evolution until humans. Moreover, the capacity of yeast to grow anaerobically, together with the ease to manipulate its genome, has made this organism one of the best systems to study mitochondrial dysfunctions. My research interests are focused on three main points:
“Progetto di Ateneo” of the University of Padova, 50.000 euro. Title of the project: Characterization of new mutations in human mitochondrial arginyl-tRNA synthetase by functional complementation in yeast
Undergraduate student positions available in the Yeast Lab.