- Terza Missione
- Il BO Live
1998 Degree in Biological Science, University of Padova.
2003 PhD in Biochemistry and Biophysics, Dep. of Biological Chemistry, University of Padova.
2003-2005 Postdoctoral research fellowship, Dep. of Biological Chemistry, University of Padova.
2006-2015 Research Associate, University of Padova.
2015-present Associate Professor of Biochemistry, Dep. of Biomedical Sciences, University of Padova.
Chemistry and Biochemistry for different Courses of the Medical School, University of Padova.
2014-present: faculty member of the PhD Program in Biomedical Sciences, University of Padova.
Our primary research interest lies in the field of phosphoproteomes (with a particular interest on acidic phosphoproteomes) and signaling pathways controlled by protein kinases. In the last years we are assisting to a rapid and enormous expansion of mass spectrometry technologies combined with innovative experimental strategies that have given a tremendous boost to the identification of phosphosites in proteins. This huge amount of phosphosites is largely uncharacterized and almost completely unknown is the impact of these modifications on protein and cell functions. Our current research projects all relate to work out regulatory mechanisms based on phosphorylation in different signal transduction pathways; this entails the analysis of phosphopeptide databases, the characterization of the cellular functions of phosphosites identified in key proteins implied in human diseases and the identification of the involved kinases. Knowledge of the functional link between kinase and specific phosphosites is indeed of keen interest as protein kinases could represent important pharmacological targets for the treatment of many human disorders.
PLOS ONE Academic Editor
CURRENT PROTEIN & PEPTIDE SCIENCE Editorial Board Member
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Editorial Board Member
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY/FRONTIERS IN MOLECULAR BIOSCIENCES Associate Editor of Cellular Biochemistry speciality section
SELECTED RECENT PUBBLICATIONS (2017-today)
FRANCHIN C., BORGO C, CESARO L., ZARAMELLA S., VILARDELL J., SALVI M.*, ARRIGONI G.*, PINNA L.A.* Re-evaluation of protein kinase CK2 pleiotropy: new insights provided by a phosphoproteomics analysis of CK2 knockout cells. Cell Mol Life Sci. 75(11):2011-2026 (2017).
KOFOED R.H., ZHENG J., FERREIRA N., LYKKE-ANDERSEN S., SALVI M., BETZER C., REIMER L., JENSEN T.H., FOG K., JENSEN PH (2017) Polo-like kinase 2 modulates a-synuclein protein levels by regulating its mRNA transcription. Neurobiology of Disease 106:49-62.
COZZA G., SALVI M. (2018) The acidophilic kinases PLK2 and PLK3: structure, function and inhibition. Current Protein & Peptide Science 19.
Piirsoo A., Piirsoo M., Kala M., Sankovski E., Lototskaja E., Levin V., Salvi M., Ustav M. Activity of CK2α protein kinase is required for efficient replication of some HPV types. PLOS Pathogens, 15(5):e1007788 (2019).
SALIZZATO V., ZANIN S., BORGO C., LIDRON E., SALVI M., RIZZUTO R., PALLAFACCHINA G., DONELLA-DEANA A. Protein kinase CK2 subunits exert specific and coordinated functions in skeletal muscle differentiation and fusogenic activity. FASEB Journal in press (2019).
D’AMORE C., BORGO C., BOSELLO-TRAVAIN V, SALIZZATO V., PINNA L.A., VENERANDO A., SALVI M. Deciphering the role of protein kinase CK2 in the maturation/stability of F508del-CFTR. BBA-Molecular Basis of Disease, in press (2019).
Co-Author of more than 70 publications on international journals.