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Present position: Lecturer of General Pathology , University of Padova. Visiting scientist, Max-Planck-Institute of Biochemistry, Germany.
Educational qualification: Ph.D. in Cell Biology and Pathology, University of Padova, Italy.
Present work experience
April 2012- March 2014: Post-doctoral fellow at Department of Proteomics and Signal Transduction, Max-Planck-Institute of Biochemistry, in the group coordinated by Prof Matthias Mann.
Research interests: Mass spectrometry-based proteomics applied to skeletal muscle.
1999 to present: Lecturer, Applied Biology and General Pathology (University of Padova).
Research interests: Activity-dependent gene regulation in skeletal muscle.
2001-2003: Postdoctoral fellow in the laboratory of Prof. Axel Ullrich, Max-Planck-Institute for Biochemistry, Martinsried, Germany.
Recipient of an EMBO long-term fellowship, 2000-2001
Recipient of a Marie Curie Individual Fellowship MCFI-2000-01360. 2001-2003, Life Sciences.
PhD in Cell Biology and Pathology in the laboratory of Prof. T. Pozzan at the Department of Biomedical Sciences, Padova.
Research interests: signal transduction and calcium signalling, single cell calcium imaging.
I use mass spectrometry (MS)-based proteomics as a tool to investigate structure-function relationships in skeletal muscle. My present interest focus both on the proteome of individual muscle fibers and on a comprehensive skeletal muscle proteome to be used as a resource in the field. I also apply MS-based proteomics to the study of alternative splicing and exon skipping of sarcomeric proteins. The possibility of interacting and collaborating with the Department of Proteomics and Signal Transduction at Max-Plack-Institute of Biochemistry offers the invaluable opportunity to be exposed to the major advances in all aspects of the field, ranging fro sample preparation, to novel instruments and to computational proteomics. I plan to apply the knowledge I could acquire so far to the context of genetic and acquired striated muscle diseases.
Stefano Schiaffino, Carlo Reggiani, Marta Murgia (2020). Fiber type diversity in skeletal muscle explored by mass spectrometry-based single fiber proteomics. HISTOLOGY AND HISTOPATHOLOGY, vol. 35, p. 239-246, ISSN: 1699-5848, doi: 10.14670/HH-18-170
Mohammad Zulkifli, John Neff, Shrishiv Timbalia, . Natalie Garza, Yingqi Chen, Jeramie Watrous, Marta Murgia, Prachi Trivedi, . Steven Anderson, Dhanendra Tomar, Roland Nilsson, Muniswamy Madesh, Mohit Jain (2020). Yeast homologs of human MCUR1 regulate mitochondrial proline metabolism. NATURE COMMUNICATIONS, p. 1-11, ISSN: 2041-1723, doi: 10.1038/s41467-020-18704-1
Marta Murgia, Jing Tan, Philipp E. Geyer, Sophia Doll, Matthias Mann and Thomas Klopstock (2019). Proteomics of cytochrome c oxidase-negative versus -positive muscle fiber sections in mitochondrial myopathy. CELL REPORTS, vol. 29, p. 3825-3834, ISSN: 2211-1247, doi: 10.1016/j.celrep.2019.11.055
Itzhak, Daniel N, Sacco, Francesca, Nagaraj, Nagarjuna, Tyanova, Stefka, Mann, Matthias, Murgia, Marta (2019). SILAC-based quantitative mass spectrometry-based proteomics quantifies endoplasmic reticulum stress in whole HeLa cells. DISEASE MODELS & MECHANISMS, vol. 12, p. 1-13, ISSN: 1754-8403, doi: 10.1242/dmm.040741
Michael Wierer, Matthias Prestel, Herbert B. Schiller, Guangyao Yan, Christoph Schaab, Sepiede Azghandi, Julia Werner, Thorsten Kessler, Rainer Malik, Marta Murgia, Zouhair Aherrahrou, Heribert Schunkert, Martin Dichgans, and Matthias Mann (2018). Compartment-resolved Proteomic Analysis of Mouse Aorta during Atherosclerotic Plaque Formation Reveals Osteoclast-specific Protein Expression. MOLECULAR & CELLULAR PROTEOMICS, vol. 17, p. 321-334, ISSN: 1535-9476, doi: 10.1074/mcp.RA117.000315
Marta Murgia, Luana Toniolo, Nagarjuna Nagaraj, Stefano Cicicliot, Vincenzo Vindigni, Stefano Schiaffino, Carlo Reggiani, Matthias Mann (2017). Single Muscle Fiber Proteomics Reveals Fiber-Type-Specific Features of Human Muscle Aging. CELL REPORTS, vol. 19, p. 2396-2409-2409, ISSN: 2211-1247, doi: 10.1016/j.celrep.2017.05.054
Stefano Schiaffino, Carlo Reggiani, Tatiana Y Kostrominova, Matthias Mann, Marta Murgia (2015). Mitochondrial specialization revealed by single muscle fiber proteomics: focus on the Krebs cycle. SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, vol. Suppl.4, p. 41-48, ISSN: 1600-0838, doi: 10.1111/sms.12606
Marta Murgia, Nagarjuna Nagaraj, Atul Deshmukh, Marlis Zeiler, Pasqua Cancellara, Irene Moretti, Carlo Reggiani, Stefano Schiaffino, Matthias Mann (2015). Single muscle fiber proteomics reveals unexpected mitochondrial specialization. EMBO REPORTS, ISSN: 1469-221X