Birth: November 28, 1980, at Pordenone (PN), Italy
Position: Researcher, Italian National Research Council (CNR)

04/2009: Ph.D. in Biosciences, cellular biology program (University of Padova)
03/2005: Laurea in Industrial Biotechnology (cum laude, University of Padova)

01/2009-12/2010: Post-doc (University of Padova)
01/2011-01/2012: Post-doc (CNR Neuroscience Institute, Padova)

Research activity in foreign laboratories:
02/2008: Prof. Renato Zenobi, laboratory of Mass Spectrometry, Swiss Federal Institute of Technology, Zurich.
05/2008: Prof. Andreas Bernkop Schnürch, Dept. Pharmaceutical Technologies, University of Innsbruck.
10/2009-04/2010 and 10/2010-11/2010: Prof. Lance Liotta, Centre of Applied Proteomics and Molecular Medicine, George Mason University, Manassas (VA).

We are developing polyphenol derivatives with the aim of improving their bioavailability and/or bioefficacy.
Different strategies can be adopted; an increase in circulating blood levels of non-metabolized natural compound may be attainable through prodrugs, while a more specific action may be achieved by concentrating the compounds at specific sites of action.
We have good expertise in assessing absorption, metabolism and distribution of polyphenol and their derivatives, using in vitro (i.e., high-resistance monolayers of cultured cell), ex vivo (i.e., Ussing chambers) and in vivo (i.e., pharmacokinetic studies in rats) assays. We have also the expertise for HPLC/UV and/or ESI-MS identification and quantification of natural polyphenols, prodrugs, as well as their hydrolysis products and metabolites in biological samples, such as blood or tissue homogenates.

  1. Biasutto L, Zoratti M.Prodrugs of quercetin and resveratrol: a strategy under development.Curr Drug Metab. 2014 Jan;15(1):77-95.
  2. Mattarei A, Azzolini M, Carraro M, Sassi N, Zoratti M, Paradisi C, Biasutto L.Acetal derivatives as prodrugs of resveratrol.Mol Pharm. 2013 Jul 1;10(7):2781-92.
  3. Biasutto L, Chiechi A, Couch R, Liotta LA, Espina V.Retinal pigment epithelium (RPE) exosomes contain signaling phosphoproteins affected by oxidative stress.Exp Cell Res. 2013 Aug 1;319(13):2113-23.
  4. Biasutto L, Szabo' I, Zoratti M.Mitochondrial effects of plant-made compounds.Antioxid Redox Signal. 2011 Dec 15;15(12):3039-59.
  5. Biasutto L, Sassi N, Mattarei A, Marotta E, Cattelan P, Toninello A, Garbisa S, Zoratti M, Paradisi C. Impact of mitochondriotropic quercetin derivatives on mitochondria. Biochim Biophys Acta. 2010 Feb;1797(2):189-96.