ER/Mitochondria contacts
Mitochondrial Ca2+ waves
3D mitochondrial structure

Description

Our research activity is mainly focused on calcium signaling and mitochondrial ion channels. In 2011, we identified the Mitochondrial Calcium Uniporter (MCU), and in 2019 we identified the mitochondrial ATP-sensitive potassium channel (mitoKATP). We study the structure/function relationship of these channels and their role in health and disease. We combine biochemical, cell-based and in vivo approaches to understand their contribution to the physiopathology of different tissues, including skeletal muscle, heart and brain.

Selected publications