Translational medicine: Tissue Enginering and Regenerative Medicine

Fibrin glue
Hyaluronic acid
Hydroxyapatite

Description

Prof. Zavan is head of Tissue Engineering and Regenerative Medicine Laboratory of Biomedical Sciences Department of Padova University, Italy. Regenerative medicine is the field of research using cells and other materials to either enhance or replace biological tissues. Tissue engineering uses biomaterials and cells to produce new tissues. Prof Zavan’s research seeks to understand how changes in stem cell activity impact tissue homeostasis and repair throughout life and to identify systemic molecules or surfaced modification are responsible for regulation of regenerative potential. Moreover aim of Prof. Zavan’s research is to develop functional grafts that have the ability to direct cellular responses, to regulate the formation and integration of multiple tissue types, and to maintain long-term functionality when introduced into the body. Her group hope to achieve these goals by elucidating the fundamental mechanisms that govern cell-biomaterial and cell-cell interactions. She has a multidisciplinary research group focused on both high quality fundamental science and translation for human health. Research in regenerative medicine within her group includes the directed differentiation of stem cells, the design of novel bioactive scaffolds and new approaches towards tissue regeneration. She has active collaborations with bioengineers, chemists and clinicians in order to study stem cell-niche interactions in vitro.

Research-at-a-glance

Translational medicine: bench to bedside. Study in pediatric field, maxillofacial surgery, orthopedic surgery, plastic surgery.

Integration of Tissue Engineering and Systems Biology

Living Functional Materials

Functional Biomaterials for regeneration of several tissue such as: bone, cartilage, skin, vessel, dental pulp, nerve, liver, tumor environment;

3D bio printing

Advanced cell based therapies

Mesenchymal stem cells

5 recent publications

  • Pulsed electromagnetic fields increase osteogenetic commitment of MSCs via the mTOR pathway in TNF-α mediated inflammatory conditions: an in-vitro study
    DLetizia Ferroni , Chiara Gardin , Moshe Salai , Shlomo Barak , Adriano Piattelli Adriano Piattelli , Hadar Amir-Barak , Barbara Zavan
    Scientific Reports 2018
  • Powder-based 3D printing for bone tissue engineering.
    Brunello G, Sivolella S, Meneghello R, Ferroni L, Gardin C, Piattelli A, Zavan B, Bressan E.
    Biotechnol Adv. 2016 Sep-Oct;34(5):740-753. doi: 10.1016/j.biotechadv.2016.03.009. Epub 2016 Apr 13. Review.
  • Graphene in Regenerative Medicine: Focus on Stem Cells and Neuronal Differentiation.
    Gardin C, Piattelli A, Zavan B.
    Trends Biotechnol. 2016 Jun;34(6):435-437. doi: 10.1016/j.tibtech.2016.01.006. Epub 2016 Feb 12. Review.
  • Nanotechnology to drive stem cell commitment.
    Bressan E, Carraro A, Ferroni L, Gardin C, Sbricoli L, Guazzo R, Stellini E, Roman M, Pinton P, Sivolella S, Zavan B.
    Nanomedicine (Lond). 2013 Mar;8(3):469-86. doi: 10.2217/nnm.13.12. Review.
  • High glucose induces adipogenic differentiation of muscle-derived stem cells.
    Aguiari P, Leo S, Zavan B, Vindigni V, Rimessi A, Bianchi K, Franzin C, Cortivo R, Rossato M, Vettor R, Abatangelo G, Pozzan T, Pinton P, Rizzuto R.
    Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1226-31. doi: 10.1073/pnas.0711402105. Epub 2008 Jan 22.

Regenerative Medicine Group


Books

Editor: Dental Stem Cells: Regenerative Potential, Editors: Zavan, Barbara, Bressan, Eriberto (Eds.) Springer, ISBN 978-3-319-33299-4


Editor in Special Issue

International Journal of Molecular Sciences "Role and Application of Mesenchymal Stem Cells on Regenerative Medicine" http://www.mdpi.com/journal/ijms/special_issues/MSCS

Frontiers in Cell and Developmental Biology The Power of Adipose-derived Mesenchymal Stem Cells
http://journal.frontiersin.org/researchtopic/4460/the-power-of-adipose-derived-mesenchymal-stem-cells