Phosphorylation Signalling in Health and Disease

Over 180 kinases are associated to diseases (http://www.cellsignal.com/reference/kinase_disease.html). Figure highlights major enzymes/pathologies on focus in our lab.

Description

We study several aspects of protein phosphorylation, a process regulated by protein kinases and phosphatases, frequently altered in cancer and other diseases. The research activities focus on the biochemical and cellular characterization of different kinases and phosphatases, the definition of their structure/function relationship, and the analysis of their signalling pathways in normal and pathological cells. Selective protein kinase inhibitors are developed as potential therapeutic drugs.

 

5 recent publications

  • Borgo C, Milan G, Favaretto F, Stasi F, Fabris R, Salizzato V, Cesaro L, Belligoli A, Sanna M, Foletto M, Prevedello L, Vindigni V, Bardini R, Donella-Deana A, Vettor R. CK2 modulates adipocyte insulin-signaling and is up-regulated in human obesity. Sci Rep. 2017 Dec 14;7(1):17569. doi:10.1038/s41598-017-17809-w.
  • Borgo C, Franchin C, Scalco S, Bosello-Travain V, Donella-Deana A, Arrigoni G,Salvi M, Pinna LA. Generation and quantitative proteomics analysis of CK2α/α'((-/-)) cells. Sci Rep. 2017 Feb 17;7:42409. doi: 10.1038/srep42409.
  • Ottaviani D, Marin O, Arrigoni G, Franchin C, Vilardell J, Sandre M, Li W, Parfitt DA, Pinna LA, Cheetham ME, Ruzzene M. Protein kinase CK2 modulates HSJ1 function through phosphorylation of the UIM2 domain. Hum Mol Genet. 2017 Feb 1;26(3):611-623. doi: 10.1093/hmg/ddw420.
  • Salizzato V, Borgo C, Cesaro L, Pinna LA, Donella-Deana A. Inhibition of protein kinase CK2 by CX-5011 counteracts imatinib-resistance preventing rpS6 phosphorylation in chronic myeloid leukaemia cells: new combined therapeutic strategies. Oncotarget. 2016 Apr 5;7(14):18204-18. doi: 10.18632/oncotarget.7569.
  • Costa R, Arrigoni G, Cozza G, Lolli G, Battistutta R, Izpisua Belmonte JC, Pinna LA, Sarno S. The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2. Biochim Biophys Acta. 2014 Apr;1844(4):722-9. doi:10.1016/j.bbapap.2014.01.014.