Education
1985: Degree cum laude in Biological Sciences, University of Padova, Italy.
1991: Ph.D. in Molecular and Cellular Biology and Pathology, University of Padova, Dept. of Biological Chemistry, Padova, Italy.

Working Experiences
1991 - 1998: Graduated Technician at the Department of Biological Chemistry, University of Padova.
1998 - 2014: Assistant Professor (“Ricercatore universitario”) at the Department of Biomedical Sciences, University of Padova
2014 – present: Associate Professor at the Department of Biomedical Sciences, University of Padova

Abroad Experiences
1989: Short term EMBO fellowship, at the Friedrich Mieschner Institute, Basel, Switzerland.
1995: CNR-NATO fellowship, at the Harvard Medical School, Boston, USA.
1998: fellowship from the "Giovanni Armenise- Harvard Foundation for advanced scientific research", at the Harvard Medical School, Boston, USA.

Teaching Activity
1992 to present: classes of Chemistry and Biochemistry for different Courses of the Medical School, University of Padova.
2005 to present: member of the teaching staff of the PhD School in Biosciences and Biotechnology and of the PhD Program in Biomedical Sciences, University of Padova; supervisor of several PhD students.

She has been always involved in projects concerning protein phosphorylation and structural and functional characterization of protein kinases and phosphatases. Her present research is mainly focused on protein kinases involved in signal transduction and regulation of cell death/survival, and on developing of specific kinase inhibitors. She is author of 87 scientific papers published in international journals (H-index 33, Google Scholar), 5 chapters on scientific books, and several communications and posters at international meetings.

  1. Girardi C, James P, Zanin S, Pinna LA, Ruzzene M. Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions. Biochim Biophys Acta. 2014 Apr 24. [Epub ahead of print]
  2. Di Maira G, Brustolon F, Pinna LA, Ruzzene M. Dephosphorylation andinactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells. Cell Mol Life Sci. 2009; 66(20):3363-3373.
  3. Di Maira G, Brustolon F, Bertacchini J, Tosoni K, Marmiroli S, Pinna LA,Ruzzene M. Pharmacological inhibition of protein kinase CK2 reverts the multidrugresistance phenotype of a CEM cell line characterized by high CK2 level.Oncogene. 2007; 26(48):6915-6926
  4. Di Maira G, Salvi M, Arrigoni G, Marin O, Sarno S, Brustolon F, Pinna LA,Ruzzene M. Protein kinase CK2 phosphorylates and upregulates Akt/PKB. Cell Death Differ. 2005; 12(6):668-677.
  5. Ruzzene M, Penzo D, Pinna LA. Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells. Biochem J. 2002; 364(Pt 1):41-47.

Full list of publications

University of Padova
MIUR (Italian Ministry of Education, Universities and Research)
AIRC (Italian Association for Cancer Research)