• PETRONILLI VALERIA
  • VALERIA PETRONILLI
    Title: C.N.R. Senior Scientist
    Telephone: 049 827-6053
    E-mail: petro@bio.unipd.it
    Group Website: [link]

Present position:
Senior Researcher, Italian National Research Council (CNR), Neuroscience Institute at the Department of Biomedical Sciences, University of Padova, Italy

Degree:
Doctor in Chemistry, University of Padova, Italy, (June 16, 1982)

Positions and honors:
2003-present: Senior Researcher, CNR Neuroscience Institute
1986-2002: Researcher, CNR
1989-1991: NATO-CNR Senior Fellow, Department of Molecular and Cell Biology, University of California at Berkeley (USA)
1998: Visiting Scientist, Center for Biomedical Imaging Technology, University of Connecticut Health Center, Farmington, Connecticut(USA).
1983-1986: Research Assistant, CNR

Study of coupling mechanisms of the reactions of mitochondrial proton pumps to the translocation of protons across the membrane and role of proton electrochemical gradient as energy coupling intermediate between the proton pumps.
Electrophysiological investigation of ionic channels in bacterial and mitochondrial
membranes by patch-clamp technique.
Study of transport mechanisms of ABC transporters by characterization of the bacterial histidine permease and its reconstitution in proteoliposomes.
Characterization of the mitochondrial permeability transition pore and study of its involvement in the pathways to programmed and accidental cell death.

 

  1. Giorgio V, von SS, Antoniel M, Fabbro A, Fogolari F, Forte M, Glick GD, Petronilli V, Zoratti M, Szabo I, Lippe G, and Bernardi P (2013) Dimers of mitochondrial ATP synthase form the permeability transition pore. Proc Natl Acad Sci U S A, 110, 5887-5892
  2. Petronilli V, Penzo D, Scorrano L, Bernardi P, Di Lisa F. (2001) The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ. J Biol Chem; 276:12030-12034
  3. Bernardi,P., Petronilli,V., Di Lisa,F., and Forte,M. (2001). A mitochondrial perspective on cell death. Trends in Biochemical Sciences, 26, 112-117
  4. Petronilli V, Miotto G, Canton M, Brini M, Colonna R, Bernardi P, Di Lisa F. (1999) Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence. Biophys J 1999; 76:725-734
  5. Petronilli,V., Costantini,P., Scorrano,L., Colonna,R., Passamonti,S., and Bernardi,P. (1994). The Voltage Sensor of the Mitochondrial Permeability Transition Pore Is Tuned by the Oxidation-Reduction State of Vicinal Thiols - Increase of the Gating Potential by Oxidants and Its Reversal by Reducing Agents. Journal of Biological Chemistry,  269, 16638-16642