Graduated in Biological Sciences at the University of Padua in March 7th 1985, discussing an experimental thesis concerning: “Synthesis of peptides containing acidic cluster as substrates and inhibitor of a c-AMP independent liver protein kinase”, reaching 110/110 cum laude.
In the Academic years 1988-93 he made his PhD-Course in "Biology Molecular And Cellular Pathology" at the University of Padua working to a thesis with the title: “Synthesis and Characterization of peptides to study protein kinase”

In the year 1992, prof. Marin has been named (nomination D.M. 27.06.1992) in the role of the University Researchers, for the grouping discipline BIO/10 (Biochemistry) at the Faculty of Medicine and Surgery with following confirmation through D.R. n° 13236/D of 22.07/1996.

Since 2006 he is Associate Professor of Biochemistry at the School of Medicine and Surgery, University of Padua.

Specific competences in the field of the protein and peptide chemistry, purification of proteins and antibodies production. Prof. Marin has devoted to the planning of peptide libraries in the laboratory of Prof. Ronald Frank to the Centre of Biotechnologies GBF (Germany) for studying substrate specificity in protein phosphorylation.

Prof. Marin develops his institutional assignments of research at the CRIBI Biothechnology Centre (University of Padua) where coordinates the activity of a research group constituted firmly by a graduated technician and a PhD student.
Further, Prof. Marin manages the Peptide Facility at CRIBI ( with a mission to supply synthetic peptide for medical and biological research. At the same time, Prof. Marin has actively participated at proteomic project of University of Padua and currently coordinates the research and proteomic server activities of the core facility for proteomic at Azienda Ospedaliera di Padova.

Research topics:

  • Protein phosphorylation and human disease: The most common cause of cystic fibrosis is the deletion of phenylalanine- 508 in the first nucleotide-binding domain in the cystic fibrosis transmembrane conductance regulator (CFTR). How this hereditary defect affects the phosphorylation of CFTR and which signaling pathways are involved in the process are open questions addressed by our research.
  • Antimicrobial peptides (AMPs): Present research is focused on the synthesis, folding and structural characterization of a new AMP, known as Myticin C, identified from the analysis of the transcriptome in Mytilus galloprovinciali.
  • Nanomedicine: Functionalization of nanoparticles with selective peptides for recognition of biological markers for early diagnosis of esophageal adenocarcinoma of the colon and rectum.
  • Proteomics: Mass spectrometry of protein and peptides.
  1. Bertacchini, J., F. Beretti, V. Cenni, M. Guida, F. Gibellini, L. Mediani, O. Marin, et al. "The Protein Kinase Akt/PKB Regulates both Prelamin A Degradation and Lmna Gene Expression." FASEB Journal 27, no. 6 (2013): 2145-2155.
  2. Botta, A., A. Malena, E. Tibaldi, L. Rocchi, E. Loro, E. Pena, L. Cenci, et al. "MBNL142 and MBNL143 Gene Isoforms, Overexpressed in DM1-Patient Muscle, Encode for Nuclear Proteins Interacting with Src Family Kinases." Cell Death and Disease 4, no. 8 (2013).
  3. Cesaro, L., O. Marin, A. Venerando, A. Donella-Deana, and L. A. Pinna. . Phosphorylation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Serine-511 by the Combined Action of Tyrosine Kinases and CK2: The Implication of Tyrosine-512 and Phenylalanine-508. Amino Acids. Vol. 45. (2013).
  4. Piller Puicher, E., R. Tomanin, M. Salvalaio, A. Friso, G. Hortelano, O. Marin, and M. Scarpa. "Encapsulated Engineered Myoblasts can Cure Hurler Syndrome: Preclinical Experiments in the Mouse Model." Gene Therapy 19, no. 4 (2012): 355-364.
  5. Turci, M., J. Lodewick, G. Di Gennaro, A. S. Rinaldi, O. Marin, E. Diani, C. Sampaio, F. Bex, U. Bertazzoni, and M. G. Romanelli. "Ubiquitination and Sumoylation of the HTLV-2 Tax-2B Protein Regulate its NF-κB Activity: A Comparative Study with the HTLV-1 Tax-1 Protein." Retrovirology 9, (2012).
  6. Alvisi, G., O. Marin, G. Pari, M. Mancini, S. Avanzi, A. Loregian, D. A. Jans, and A. Ripalti. "Multiple Phosphorylation Sites at the C-Terminus Regulate Nuclear Import of HCMV DNA Polymerase Processivity Factor ppUL44." Virology 417, no. 2 (2011): 259-267.
  7. Boijeaf Gennäs, G., L. Mologni, S. Ahmed, M. Rajaratnam, O. Marin, N. Lindholm, M. Viltadi, C. Gambacorti-Passerini, L. Scapozza, and J. Yli-Kauhaluoma. "Design, Synthesis, and Biological Activity of Urea Derivatives as Anaplastic Lymphoma Kinase Inhibitors." Chemmedchem 6, no. 9 (2011): 1680-1692.
  8. Tripodi, F., C. Cirulli, V. Reghellin, L. Brambilla, O. Marin, and P. Coccetti. "Nutritional Modulation of CK2 in Saccharomyces Cerevisiae: Regulating the Activity of a Constitutive Enzyme." Molecular and Cellular Biochemistry 356, no. 1-2 (2011): 269-275.
  9. Venerando, A., O. Marin, G. Cozza, V. H. Bustos, S. Sarno, and L. A. Pinna. "Erratum: Isoform Specific Phosphorylation of p53 by Protein Kinase CK1 ((2010) 67 (1105-1118))." Cellular and Molecular Life Sciences 68, no. 5 (2011): 919.
  10. Pagano, M. A., O. Marin, G. Cozza, S. Sarno, F. Meggio, K. J. Treharne, A. Mehta, and L. A. Pinna. "Cystic Fibrosis Transmembrane Regulator Fragments with the Phe508 Deletion Exert a Dual Allosteric Control Over the Master Kinase CK2." Biochemical Journal 426, no. 1 (2010): 19-29.
  11. Silic-Benussi, M., O. Marin, R. Biasiotto, D. M. D'Agostino, and V. Ciminale. "Effects of Human T-Cell Leukemia Virus Type 1 (HTLV-1) p13 on Mitochondrial K+ Permeability: A New Member of the Viroporin Family?" FEBS Letters 584, no. 10 (2010): 2070-2075.

a) European Patent EP03005186 "Anaplastic lymphoma kinase assay, reagents and compositions thereof", INT (Istituto Nazionale Tumori), designando inventori: L.A. Pinna, A. Donella-Deana, O. Marin, L. Moloni, R. Gunby, C. Gambacorti-Passerini, L. Scapozza.

b) Patent: US20080175837, “DPP4 inhibitor and pharmaceutical application thereof”, depositata da: Ajinomoto Co., Inc.,Ijichi C, Yamada N, Hatanaka T, Takehana K, Miotto G, Marin O, Carpi A, Bertaggia D.