1998. Degree in Biological Sciences, University of Padova.
1999 – 2002. PhD in Biochemistry and Biophysics at the Department of Biological Chemistry, University of Padova. Title of PhD Thesis: “Study on the cellular role of a protein kinase with particular features in the yeast Saccharomyces cerevisiae”.
2002 – 2004. Post-Doc fellow (MIUR) at the Department of Biological Chemistry, University of Padova. Research project: “Functional analysis of the YGR262c/BUD32 gene of Saccharomyces cerevisiae”.
2005 – 2008. Post-Doc fellow (ARC, Association pour la Recherche sur le Cancer; ANR, Agence Nationale de la Recherche) at the CGM (Centre de Genetique Moleculaire - CNRS) of Gif sur Yvette (France). Research project: “Study of the EKC complex and its involvement in transcription: a new biochemical entity bearing putative endopeptidase and kinase activities”.
2009 – 2011. Post-Doc fellow (nEUROsyn) at the VIMM (Venetian Institute of Molecular Medicine) of Padova. Research project: "Molecular mechanisms underlying synaptic dysfunction in prototypic neurodegenerative diseases related to protein misfolding".
2011 – . Reseach Associate, School of Medicine and Surgery, SSD BIO10 – Biochemistry, Department of Biomedical Sciences, University of Padova.

My scientific activity is focused on Biochemistry, Molecular Biology and Genetics of the yeast Saccharomyces cerevisiae, a powerful model organism to study many aspects of the eukaryotic cell biology.
Current research topics are:
1) to use yeast as model system in order to investigate the molecular defect causing the mitochondrial dysfunctions observed in Huntington’s Disease (HD) patients;
2) to analyse, by functional complementation assays in yeast, the effects of point mutations of the Plasma membrane Ca2+-ATPase (PMCA) proteins, key players in Ca2+ homeostasis, genetically linked to different neurological diseases;
3) to perform the molecular dissection of the protein-protein interaction map of the VHL (von Hippel-Lindau) factor, a tumor suppressor protein related to familial forms of cancer, by yeast two-hybrid assay.
Saccharomyces cerevisiae is also particularly relevant in food production, and some genetic analysis of specific wine strains are currently in progress, by the partnership with Private Companies.
Full technical equipment for yeast manipulation is available in the Yeast Lab, and extensive expertise of its members also allows to participate as collaborators to additional research projects. The Yeast Lab is always open to motivated people interested in science, ready to spend time working at the bench or in scientific discussions, but also to have nice coffe-breaks, and (sometimes) to drink a glass in the wonderful center of Padova: of course, only wine or beer are allowed.

  1. Lopreiato R., Giacomello M., Carafoli E. (2014) The Plasma Membrane Calcium Pump: New Ways to Look at an Old Enzyme. J Biol Chem 289, 10261-10268
  2. Giacomello M., Hudec R., Lopreiato R. (2011) Huntington's disease, Calcium and mitochondria. BioFactors, 37, 206-18
  3. Costa V., Giacomello M., Hudec R., Lopreiato R., Ermak G., Lim D., Malorni W., Davies K.J.A., Carafoli E., Scorrano L. (2010) Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO Mol Med, 2, 490-503
  4. Hecker A.*, Lopreiato R.*, Graille M., Collinet B., Forterre P., Libri D., van Tilbeurgh H. (2008) Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex. EMBO J, 27, 2340-2351
  5. Kisseleva-Romanova E., Lopreiato R., Baudin-Baillieu A., Rousselle J.C., Ilan L., Hofmann K., Namane A., Mann C., Libri D. (2006) Yeast homolog of a Cancer-Testis antigen defines a new transcription complex. EMBO J, 25, 3576-85

2002. “Franco Tatò” Award for PhD Thesis, from the Italian Society of General Microbiology and Microbial Biotechnologies.

University of Padova, PRAT2011: “Mitochondrial dysfunctions in neurodegeneration: a study in a yeast model of Huntington's Disease”
Research Partnership with IB Srl: “Systematic Genotyping of wine yeast strains of the genus Saccharomyces”
MIUR, Funds ex-60%