- Vivi Padova
- Il Bo
1974, University of Padova, Degree in Biological Sciences (110/110 cum laude)
1975-1981: Fellow, Institute of Physiology, University of Padova
1981-2001: Assistant Professor, University of Padova
2001- to present: Associate Professor of Physiology, University of Padova
Research activity is mainly devoted to the study of contractile and electrophysiological properties of skeletal muscle, with reference to contractile and regulatory proteins profiles and to the modifications caused by altered levels of activity (disuse, denervation and microgravity) on functional properties of skeletal muscles.
The most important results obtained are related to altered functional properties of muscles from α-sarcoglycan-deficient mice and to the relationship between the expression of anomalous fats troponin T isoforms and the reduced force development in FRG1 mice which are the model for human FSHD. Other important results are related to the role of sphingosine 1-phosphate signaling in regulating muscle growth and regeneration, the role of this lipid being presently investigated in the mdx mice, model of human Duchenne Muscular Dystrophy.
Present scientific activity is mainly devoted to the study of (1) contractile and electrophysiological properties of skeletal muscle,
(2) modifications produced by altered levels of activity on contractile properties, (3) motor and non-motor influences on the differentiation of regenerating muscle, (4) activation processes in aged muscles, (5) effects of simulated microgravity and spaceflight on muscular trophism, and (6) role of sphingosine 1-phosphate signaling in muscle physiology, regeneration and dystrophy.
Zanin M, Germinario E, Dalla Libera L, Sandonà D, Sabbadini R.A, Betto R, Danieli-Betto D. Trophic action of sphingosine 1-phosphate in denervated rat soleus muscle. Am J Physiol 294: C36-C46, 2008
Danieli-Betto D, Peron S, Germinario E, Zanin M, Sorci G, Sandonà D, Betto R. Sphingosine 1-phosphate signaling is involved in skeletal muscle regeneration. Am J Physiol 298: C550-558, 2010
Germinario E, Peron S, Toniolo L, Betto R, Cencetti F, Donati C, Bruni P, Danieli-Betto D. S1P2 receptor promotes mouse skeletal muscle regeneration. J Appl Physiol 113: 707-713, 2012
Pierno S, Camerino GM, Cannone M, Liantonio A, De Bellis M, Digennaro C, Gramegna G, De Luca A, Germinario E, Danieli-Betto D, Betto R, Dobrowolny G, Rizzuto E, Musarò A, Desaphy JF, Conte Camerino D. Paracrine effects of IGF-1 overexpression on the functional decline due to skeletal muscle disuse: molecular and functional evaluation in hindlimb unloaded MLC/mIgf-1 transgenic mice. PlosOne 2013 Jun 3;8(6):e65167.
Sancisi V, Germinario E, Esposito A, Morini E, Peron S, Moggio M, Tomelleri G, Danieli-Betto D, Tupler R. Altered Tnnt3 characterizes selective weakness of fast fibers in mice overexpressing FSHD Region Gene 1 (FRG1). Am J Regul Integr Comp Physiol 306:R124-R137, 2014