Oxidative Stress and Thiol Redox Regulation

Description

Our interests are above referred to oxidative stress, redox regulation in normal and tumoral cells. In particular, our studies are developed mitochondrial redox regulation especially in relation with glutathione and thioredoxin systems. Thioredoxin system- thioredoxin, thioredoxin reductase and peroxiredoxins-is analyzed also in relation to redox signalling. Inhibitors of thioredoxin reductase such as metal complexes are evaluated and consequently the redox state of the protein targets are investigated.

A second topic of interest is the role of antioxidant molecules in human nutrition.

 

Awards

J Med Chem Award 2012.pdf J Med Chem Award 2012

Highly Cited Paper Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

5 recent publications

  1. Scalcon V, Salmain M, Folda A, Top S, Pigeon P, Shirley Lee HZ, Jaouen G, Bindoli A, Vessières A, Rigobello MP. Tamoxifen-like metallocifens target the thioredoxin system determining mitochondrial impairment leading to apoptosis in Jurkat cells. Metallomics. 2017 Jul 19;9(7):949-959. doi: 10.1039/c7mt00121e. PubMed PMID: 28636040.
  2. Karaca Ö, Scalcon V, Meier-Menches SM, Bonsignore R, Brouwer JMJL, Tonolo F, Folda A, Rigobello MP, Kühn FE, Casini A. Characterization of Hydrophilic Gold(I) N-Heterocyclic Carbene (NHC) Complexes as Potent TrxR Inhibitors Using Biochemical and Mass Spectrometric Approaches. Inorg Chem. 2017 Nov 20;56(22):14237-14250. doi: 10.1021/acs.inorgchem.7b02345. Epub 2017 Nov 2. PubMed PMID: 29095609.
  3. Scalcon V, Top S, Lee HZ, Citta A, Folda A, Bindoli A, Leong WK, Salmain M, Vessières A, Jaouen G, Rigobello MP. Osmocenyl-tamoxifen derivatives target the thioredoxin system leading to a redox imbalance in Jurkat cells. J Inorg Biochem. 2016 Jul;160:296-304. doi: 10.1016/j.jinorgbio.2016.04.005. Epub 2016 Apr 13. PubMed PMID: 27130146.
  4. Folda A, Citta A, Scalcon V, Calì T, Zonta F, Scutari G, Bindoli A, Rigobello MP. Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State. Sci Rep. 2016 Mar 15;6:23071. doi: 10.1038/srep23071. PubMed PMID: 26975474; PubMed Central PMCID: PMC4791683.
  5. Bindoli A, Rigobello MP. Principles in redox signaling: from chemistry to functional significance. Antioxid Redox Signal. 2013 May 1;18(13):1557-93. doi: 10.1089/ars.2012.4655. Epub 2013 Feb 19. Review. PubMed PMID: 23244515.