Nanoparticles and peptides in biomedicine

Description

We are interested in the mechanisms of the biomedical and toxicological/ pathological effects of nanosystems for therapy and diagnosis (nanothernostics) at the biochemical, cellular and organismic level. We are engaged in i) studying the cytotoxic, pro-inflammatory, immunomodulatory and bio-compatibility of nanoparticles; ii) assessing and engineering their modulation by peptides (included insect and mold AMPs ), microbial and host-derived molecules (nanoparticle protein corona); iii) using this information to optimise the design and performance of multi-layered targeted nanoassemblies for drug delivery or PDT.

5 recent publications

  • Fedeli C, Segat D, Tavano R, De Franceschi G, de Laureto PP, Lubian E, Selvestrel F, Mancin F, Papini E. Variations of the corona HDL:albumin ratio determine distinct effects of amorphous SiO2 nanoparticles on monocytes and macrophages in serum. Nanomedicine (Lond). 2014 Mar 24.
  • Selvestrel F, Moret F, Segat D, Woodhams JH, Fracasso G, Echevarria IM, Ba├╣ L, Rastrelli F, Compagnin C, Reddi E, Fedeli C, Papini E, Tavano R, MacKenzie A, Bovis M, Yaghini E, MacRobert AJ, Zanini S, Boscaini A, Colombatti M, Mancin F. Targeted delivery of photosensitizers: efficacy and selectivity issues revealed by multifunctional ORMOSIL nanovectors in cellular systems. Nanoscale. 2013 Jul 7;5(13):6106-16.
  • Fedeli C, Selvestrel F, Tavano R, Segat D, Mancin F, Papini E. Catastrophic inflammatory death of monocytes and macrophages by overtaking of a critical dose of endocytosed synthetic amorphous silica nanoparticles/serum protein complexes. Nanomedicine (Lond). 2013 Jul;8(7):1101-26.
  • Segat D, Tavano R, Donini M, Selvestrel F, Rio-Echevarria I, Rojnik M, Kocbek P, Kos J, Iratni S, Sheglmann D, Mancin F, Dusi S, Papini E. Proinflammatory effects of bare and PEGylated ORMOSIL-, PLGA- and SUV-NPs on monocytes and PMNs and their modulation by f-MLP. Nanomedicine (Lond). 2011 Aug;6(6):1027-46.
  • Tavano R, Segat D, Reddi E, Kos J, Rojnik M, Kocbek P, Iratni S, Scheglmann D, Colucci M, Echevarria IM, Selvestrel F, Mancin F, Papini E. Procoagulant properties of bare and highly PEGylated vinyl-modified silica nanoparticles. Nanomedicine (Lond). 2010 Aug;5(6):881-96.

 

Grants

  • European Research Council
  • PRIN
  • Universit├á di Padova