Computational and Molecular Interactomics

Description

We develop both bioinformatics methods and databases, which are then applied to in silico analysis of complex biological systems (e.g. cancer, circadian rhythm), suggesting possible novel links in the cellular protein interaction network. Molecular validation in vivo is finally performed in yeast cells by functional assays (e.g. two-hybrid), also including genetics and mutational analysis.

5 recent publications

  • CDKN2A Unclassified Variants in Familial Malignant Melanoma: Combining Functional and Computational Approaches for Their Assessment. Scaini MC, Minervini G, Elefanti L, Ghiorzo P, Pastorino L, Tognazzo S, Agata S, Quaggio M, Zullato D, Bianchi-Scarrà G, Montagna M, D'Andrea E, Menin C, Tosatto SC. Hum Mutat. 2014 Jul;35(7):828-40.
  • The plasma membrane calcium pump: new ways to look at an old enzyme. Lopreiato R, Giacomello M, Carafoli E. J Biol Chem. 2014 Apr 11;289(15):10261-8.
  • Channel Formation by Yeast F-ATP Synthase and the Role of Dimerization in the Mitochondrial Permeability Transition. Carraro M, Giorgio V, Sileikyte J, Sartori G, Forte M, Lippe G, Zoratti M, Szabò I, Bernardi P. J Biol Chem. 2014 Jun 6;289(23):15980-15985.
  • Fly cryptochrome and the visual system. Mazzotta G, Rossi A, Leonardi E, Mason M, Bertolucci C, Caccin L, Spolaore B, Martin AJ, Schlichting M, Grebler R, Helfrich-Förster C, Mammi S, Costa R, Tosatto SC. Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6163-8.
  • MobiDB: a comprehensive database of intrinsic protein disorder annotations. Di Domenico T, Walsh I, Martin AJ, Tosatto SC. Bioinformatics. 2012 Aug 1;28(15):2080-1.

Grants

  • FIRB Futuro in Ricerca
  • Ministero della Salute
  • Fondazione CARIPARO
  • AIRC
  • COST Action
  • Università di Padova

 

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